|
KMID : 0811720040080000195
|
|
Korean Journal of Physiology & Pharmacology
2004 Volume.8 No. 0 p.195 ~ p.0
|
|
|
Spinal Microglia Following Peripheral Nerve Injury is not Related to the Manifestation of Mechanical Allodynia in a Rat Model of Neuropathic Pain
|
|
Lee Jae-Hee
Kim Myung-Ah
Back Seung-Keun
Hong Seung-Kil
Na Heung-Sik
|
|
|
Abstract
|
|
|
Accumulating evidence has proposed that activation of microglia in the spinal cord following peripheral nerve injury contributes to the generation of neuropathic pain, which is characterized by pain hypersensitivity to innocuous mechanical stimuli, a phenomenon known as mechanical allodynia. We examined whether the manifestation of mechanical allodynia depended on activation of spinal microglia following peripheral nerve injury. To this aim, we compared the spinal expression of OX42, a marker of microglia, and hosphor-p38 (p-p38) in the two groups; one group (allodynic group) exhibited the robust mechanical allodynia sign 2 weeks following the unilateral tight ligation of L5 spinal nerve, whereas the other group (non-allodynic group) did not show the sign despite the same nerve injury. We found that immunofluorescence and protein levels of OX42 and p-p38 were increased in the spinal cord ipsilateral to spinal nerve injury. However, the increased levels of OX42 and p-p38 were not different in the both groups. These results suggest that activation of microglia in the spinal cord following peripheral nerve injury may be not related to, at least, the maintenance of neuropathic pain.
Source: Korean Journal of Physiology & Pharmacology.2004 Oct;8(Suppl I):S142-S142
|
|
|
KEYWORD
|
|
|
Peripheral nerve injury, Mechanical allodynia, Spinal hyperactive microglia, OX42, Phospho-p38
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|